Postmarketing safety data of the previous CFC version were also evaluated during the FDA review of the new drug application for Primatene ® MIST HFA. With regard to safety of Primatene ® MIST HFA, the most common adverse events reported were tremor, followed by chest discomfort. The efficacy of Primatene ® MIST HFA was comparable with that of Primatene ® MIST CFC. The results demonstrated significant bronchodilator efficacy of Primatene ® MIST HFA compared with placebo, with a between-group difference of 27.83 AUC 0-6hr of Δ%FEV1 (95% CI, 11.99-43.68 P <.05). The primary efficacy end point studied was the mean area under the curve (AUC) of the change in 1-second forced expiratory volume (Δ%FEV1) from same-day, predose baseline to 6 hours post dose (AUC 0-6hr of Δ%FEV1) at week 12. The results demonstrated that Primatene ® MIST HFA is safe and effective in relieving mild symptoms of intermittent asthma in adolescents and adults. The duration of treatment was 3 months, followed by a 3-month safety extension period. Patients were randomized 4:1:1 to receive Primatene ® MIST HFA 250 mcg (two 125 mcg inhalations), placebo, or Primatene ® MIST CFC 440 mcg (two 220 mcg inhalations), respectively, 4 times daily. The efficacy and safety of Primatene ® MIST HFA were established in a phase 3, randomized, double-blind, placebo- and active-controlled (Primatene ® MIST CFC), parallel-group study of patients 12 years and older with stable asthma. SUMMARY OF CLINICAL STUDIES AND POSTMARKETING DATA FOR PRIMATENE ® MIST The previous version was indicated for patients 4 years and older. 1,2 Primatene ® MIST HFA is approved for patients 12 years and older. 2 Critical instructions and a dose indicator are provided directly on the inhaler. 2 Further, because Primatene ® MIST HFA is a suspension, the inhaler must be shaken prior to each use to ensure that the proper dose is administered. 2 The efficacy remains comparable at the lower dose. 2 Both contain the same active ingredient, L-epinephrine however, Primatene ® MIST HFA contains a 43% lower dose of epinephrine than the previously marketed CFC version. There are several differences between Primatene ® MIST CFC and the new Primatene ® MIST HFA. 1,6 It delivers 0.125 mg of L-epinephrine per spray and contains inactive ingredients such as dehydrated alcohol (1%), HFA 134a, polysorbate 80, and thymol. Primatene ® MIST HFA is a metered-dose inhaler that is FDA-approved for OTC use for the temporary relief of mild symptoms of intermittent asthma, such as wheezing, tightness of chest, and shortness of breath. 6 For the convenience of this guide, the new Primatene ® MIST containing HFA will be referred to as Primatene ® MIST HFA and the previous version will be referred to as Primatene ® MIST CFC. The product was launched in December 2018. 2,4,5 The new formulation of Primatene ® MIST uses hydrofluoroalkane (HFA) as the propellant, and it was approved by the FDA for OTC use on November 7, 2018. During discussions with patients, pharmacists can counsel them on important points regarding safety, appropriate dosing and use to guide them regarding treatments.Ī prior formulation of Primatene ® MIST, approved by the FDA more than 50 years ago, used chlorofluorocarbon (CFC) propellant and was subsequently discontinued in 2011 as a part of the overall efforts of the Montreal Protocol of Substances that Deplete the Ozone Layer and the Clean Air Act of 1990 to phase out ozone-depleting CFC propellants. 2 Pharmacists are ideally positioned to answer questions, educate patients, and offer support to patients who are interested in using the new and improved Primatene ® MIST. 1,2,3 Studies have demonstrated that it is safe and effective in patients with intermittent asthma when used as directed. The new Primatene ® MIST, an epinephrine inhalation aerosol bronchodilator (0.125 mg L-epinephrine), is the only FDA-approved, over-the-counter (OTC) asthma medicine inhaler for the temporary relief of mild symptoms of intermittent asthma. This article is sponsored by Amphastar Pharmaceuticals, Inc.
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When in port, and the duty of the ship will admit of the indulgence, a boat is to be ready at nine o’clock every morning, to carry any person, who may have permission, on shore another boat to go at one, and another at a sufficient time before sun-set to admit of her return to the ship at that time. These are always to be piped down after beating the retreat from quarters at sea, and after hoisting the boats up when at anchor.Ĩth. In the winter the hands are to be turned up at seven o’clock and the decks cleaned by 7 bells when the hammocks are to be got up. The boats required for the duty of the ship are to be hoisted out, and the decks scrubbed and washed the comings, ladders, and channels & gratings, are to be particularly well scrubbed the yards squared and hammock cloths spread by seven o’clock. When in harbour and other duty does not prevent it, the hands are to be turned up in the summer season at 5. When a Commodore arrives in port, the sails are to be loosened and taken in, agreeably to his movements but should any strange ship appear off the harbour, no boat is to board them, until it be ascertained that they are friends.ħth. And when a commanding officers gets underweigh, his motions if the weather will permit, are to be followed till he is clear of the harbour. When in harbour and particular duty on board prevents the motions of the senior officers from being followed, a message is always to be sent specifying the reasons which so prevented it. If in harbour and weather will permit, the sails are to be loosed and every evolution practised which may occur in action at sea.Ħth. When in harbour or at sea, and particular duty does not interfere, or when in company of a senior officer, who does not make the signal periodically, Monday Tuesday and Friday mornings are to be appropriated for the exercise of the great guns and small arms on which day, every officer on the spot is particularly required to attend. When the service will allow of leave being granted to the seamen and marines to go on shore, a regular list is to be kept, and none are to be permitted, but by the first lieutenant or by his consent.ĥth. Should it rain before they are perfectly dry, they are to be taken down, and put into clean half tubs under the charge of the sentinel at the cabin door.Ĥth. Clothes lines to be cut out of white line are to be kept for that particular purpose by the Boatswain’s yeoman the lines to be rove and marked off the preceding night, and the linen hung between the fore and main shrouds at sea. On Saturday mornings, the Ship Cooks are to be called at 4 o’clock, to boil water for washing the ship’s company’s clothes the hands to be turned up at 6 and to continue washing until half past 7 o’clock. Each Lieutenant is to take a copy of the General Orders, and those issued separately to the officers in their respective departments after which he is to sign his name in the orderly book, which signature is to be considered as an acknowledgement of his having so done.ģrd. Having thought proper to establish the following Rules for the guidance of the officers and the ships company under my command, it is strictly required that no deviation whatever take place without my knowledge and concurrence, but that every person obey them in the fullest sense, together with any additional instructions that I may think proper to insert in the orderly book, for the good of the United States Navy.Ģnd. 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This finding motivated us to conduct our own SWNTs suspensions that are stable over time, compared to such alkylamide solvents as dimethylformamide, diethylacetamide, and dimethylpropanamide. A number of amide solvents we re studied in ,Īnd DMAA was shown to be best for preparation of In impregnating nanotubes into polymer matrices. Suspensions of carbon nanotubes in dimethylacetamide (DMAA) have found wide practical application Preparation of stable suspensions of individual nanotubes with a certain set of chiralities. Single-walled carbon nanotubes (SWNTs) requires the Practical application of the unique properties of Suspensions, Raman spectroscopy, decomposition of spectra, calculating SWNT diameters, estimating chirality Keywords: dimethylacetamide, cholic acid, dispersing nanotubes, single-walled carbon nanotubes, SWNT Of individual nanotubes in suspension is described in detail. A technique for processing spectral data to estimate the diameters and chiralities In individual and mixed amide solvents on the type of solvent, the mass of nanotubes, and the concentration The dependence of the degree of single-walled carbon nanotube (SWNT) dispersion Of Experimental Mineralogy, Chernogolovka, Moscow oblast, 142432 RussiaĪbstract-A way of dispersing single-walled carbon nanotubes in preparing stable suspensions with high concentrations of individual nanotubes in amide solvents is described. Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, 153045 Russia 1847–1852.ĭispersion of Single-Walled Carbon Nanotubes in DimethylacetamideĪnd a Dimethylacetamide–Cholic Acid MixtureĪ. Kiselev, 2016, published in Zhurnal Fizicheskoi Khimii, 2016, Vol. ISSN 0036-0244, Russian Journal of Physical Chemistry A, 2016, Vol. Are you a beginner who started playing last month? Do you usually like this style of music? 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